High-throughput analysis of the steroid profile in placental cell cultures to evaluate endocrine disrupting effects of contaminant exposure

• Matthew Phillips

Human placental JEG-Three cells preserve a excessive P450 aromatase exercise and are subsequently appropriate to judge how contaminants could intrude with the routes concerned in estrogen synthesis throughout being pregnant. This has been historically assessed by measuring aromatase exercise by means of the quantity of tritiated water (3H2O) shaped in the course of the aromatization…