Osteochondral Defects Healing Using Extracellular Matrix Mimetic Phosphate/Sulfate Decorated GAGs-Agarose Gel and Quantitative Micro-CT Evaluation

• Matthew Phillips

Tissue engineering has a significant emphasis in creating tissue particular extracellular ambiance by altering chemical functionalities of scaffold supplies. Heterogeneity of osteochondral tissue necessitates tailorable bone and cartilage particular extracellular atmosphere. Carboxylate- and sulfate-functionalized glycosaminoglycans (GAGs) in cartilage extracellular matrix (ECM) create an acidic atmosphere to assist chondrogenic exercise whereas phosphate-rich atmosphere in bone allows…