The distinct MHC-unrestricted immunobiology of innate-like and adaptive-like human γδ T cell subsets-Nature’s CAR-T cells

• Matthew Phillips

Distinct innate-like and adaptive-like immunobiological paradigms are rising for human γδ T cells, supported by a mixture of immunophenotypic, T cell receptor (TCR) repertoire, purposeful, and transcriptomic information. Proof of the γδ TCR/ligand recognition modalities that respective human subsets make the most of is accumulating.   Though many questions stay unanswered, one superantigen-like modality options…